Publications

Selected Publications

Pausch P, Abdelshahid M, Steinchen W, Schäfer H, Gratani FL, Freibert SA, Wolz C, Turgay K, Wilson DN and Bange G. 2020. Structural Basis for Regulation of the Opposing (p)ppGpp Synthetase and Hydrolase within the Stringent Response Orchestrator Rel. Cell Rep. 32(11):108157.
PubMed Link

Schnirch L, Nadler-Holly M, Siao SW, Frese CK, Viner R and Liu F. 2020. Expanding the depth and sensitivity of cross-link identification by differential ion mobility using high-field asymmetric waveform ion mobility spectrometry. Anal. Chem. 92(15):10495-10503.
PubMed Link

Dougan DA, Alver R and Turgay K. 2020. Exploring a potential Achilles heel of Mycobacterium tuberculosis: defining the ClpC1 interactome. FEBS J. Jun 17 (Epub ahead of print).
PubMed Link

Broglia L, Lécrivain AL, Renault TT, Hahnke K, Ahmed-Begrich R, Le Rhun A and Charpentier E. 2020. An RNA-seq based comparative approach reveals the transcriptome-wide interplay between 3′-to-5′ exoRNases and RNase Y. Nat. Commun. 11(1):1587.
PubMed Link

Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN and Turgay K. 2020. The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet. 16(3):e1008275.
PubMed Link

Bratovič M, Fonfara I, Chylinski K, Gálvez EJC, Sullivan TJ, Boerno S, Timmermann B, Boettcher M and Charpentier E. 2020. Bridge helix arginines play a critical role in Cas9 sensitivity to mismatches. Nat. Chem. Biol. 16(5):587-595.
PubMed Link

Righetti F, Materne SL, Boss J, Eichner H, Charpentier E and Loh E. 2020. Characterization of a transcriptional TPP riboswitch in the human pathogen Neisseria meningitidis. RNA Biol. 17(5):718-730.
PubMed Link

Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R and Koonin EV. 2020. Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants. Nat. Rev. Microbiol. 18(2):67-83.
PubMed Link

Mulvenna N, Hantke I, Burchell L, Nicod S, Bell D,Turgay K and Wigneshweraraj S. 2019. Xenogeneic Modulation of the ClpCP Protease of Bacillus subtilis by a Phage-Encoded Adaptor-Like Protein. J. Biol. Chem. 294(46):17501-17511.
PubMed Link

Zhan X, Li B, Zhan X, Schlüter H, Jungblut PR and Coorssen JR. 2019. Innovating the Concept and Practice of Two-Dimensional Gel Electrophoresis in the Analysis of Proteomes at the Proteoform Level. Proteomes 7(4).
PubMed Link

Ratner HK, Escalera-Maurer A, Le Rhun A, Jaggavarapu S, Wozniak JE, Crispell EK, Charpentier E and Weiss DS. 2019. Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence. Mol. Cell 75(3):498-510.
PubMed Link

Davies K and Charpentier E. 2019. Finding her niche: an interview with Emmanuelle Charpentier. CRISPR J. 2:17-22.
PubMed Link

Charpentier E, Elsholz A and Marchfelder A. 2019. CRISPR-Cas: more than 10 years and still full of mysteries. RNA Biol. 16(4):377-379.
PubMed Link

Lander ES, Baylis F, Zhang F, Charpentier E, Berg P, Bourgain C, Friedrich B, Joung JK, Li J, Liu D, Naldini L, Nie JB, Qiu R, Schoene-Seifert B, Shao F, Terry S, Wei W and Winnacker EL. 2019. Adopt a moratorium on heritable genome editing. Nature 567(7747):165-168.
PubMed Link

Le Rhun A, Escalera-Maurer A, Bratovič M and Charpentier E. 2019. CRISPR-Cas in Streptococcus pyogenes. RNA Biol. 16(4):380-389.
PubMed Link

Schäfer H and Turgay K. 2019. Spx, a versatile regulator of the Bacillus subtilis stress response. Curr. Genet. 65(4):871-876.
PubMed Link

Hengge R, Häussler S, Pruteanu M, Stülke J, Tschowri N and Turgay K. 2019. Recent advances and current trends nucleotide second messenger signaling in bacteria. J. Mol. Biol. 431(5):908-927.
PubMed Link

Schäfer H, Heinz A, Sudzinová P, Voß M, Hantke I, Krásný L and Turgay K. 2019. Spx, the central regulator of the heat and oxidative stress response in B. subtilis can repress transcription of translation-related genes. Mol. Microbiol. 111(2):514-533.
PubMed Link

Hantke I, Schäfer H, Janczikowski A and Turgay K. 2019. YocM a small heat shock protein can protect Bacillus subtilis cells during salt stress. Mol. Microbiol. 111(2):423-440.
PubMed Link

Ugolini M and Sander LE. 2019. Dead or alive: how the immune system detects microbial viability. Curr. Opin. Immunol. 56:60-66.
PubMed Link

Lécrivain AL, Le Rhun A, Renault TT, Ahmed-Begrich R, Hahnke K and Charpentier E. 2018. In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes. Proc. Natl. Acad. Sci. U. S. A. 115(46):11814-11819.
PubMed Link

Broglia L, Materne S, Lécrivain AL, Hahnke K, Le Rhun A and Charpentier E. 2018. RNase Y-mediated regulation of the streptococcal pyrogenic exotoxin B. RNA Biol. 15(10):1336-1347.
PubMed Link

Tsatsaronis JA, Franch-Arroyo S, Resch U and Charpentier E. 2018. Extracellular Vesicle RNA: A universal mediator of microbial communication? Trends Microbiol. 26(5):401-410.
PubMed Link

Hille F, Richter H, Wong SP, Bratovič M, Ressel S and Charpentier E. 2018. The biology of CRISPR-Cas: Backward and forward. Cell 172(6):1239-1259.
PubMed Link

Charpentier E. 2018. Spotlight on… Emmanuelle Charpentier. FEMS Microbiol. Lett. 365(4).
PubMed Link

Labuhn M, Adams FF, Ng M, Knoess S, Schambach A, Charpentier EM, Schwarzer A, Mateo JL, Klusmann JH and Heckl D. 2018. Refined sgRNA efficacy prediction improves large- and small-scale CRISPR-Cas9 applications. Nucleic Acids Res. 46(3):1375-1385.
PubMed Link

Hurwitz JL, Jones BG, Charpentier E and Woodland DL. 2018. Hypothesis: RNA and DNA Viral Sequence Integration into Mammalian Host Genome Supports Long-Term B Cell and T Cell Adaptive Immunity. Viral Immunol. 30(9):628-632.
PubMed Link

For past publications of Emmanuelle Charpentier and members of her teams at other academic institutions in Germany, Sweden and Austria, please visit: <>.